Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureRuifu Chemical Supply Irbesartan Intermediates: Irbesartan CAS 138402-11-6 Cyano-Irbesartan CAS 138401-24-8 Trityl Irbesartan CAS 138402-10-5 TTBB CAS 124750-51-2 Irbesartan Side Chain Hydrochloride CAS 151257-01-1| Item | Specifications |
| Appearance | White to Almost White Crystalline Powder |
| Purity / Analysis Method | >99.0% (HPLC) |
| Loss on Drying | <0.50% |
| Residue on Ignition | <0.20% |
| Total Impurities | <1.00% |
| Proton NMR Spectrum | Conforms to Structure |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Irbesartan (CAS: 138402-11-6) |
Description:
Specifications:
Package & Storage:
| Chemical Name | 2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one Hydrochloride |
| Synonyms | Irbesartan Side Chain Hydrochloride; Irbesartan Lactam Impurity; Irbesartan Impurity A; 2-Butyl-4-spirocyclopentane-2-imidazolin-5-one Hydrochloride; 2-Butyl-1,3-diaza-spiro[4.4]non-1-en-4-one HCl |
| CAS Number | 151257-01-1 |
| CAT Number | RF-PI1894 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C11H18N2O·HCl |
| Molecular Weight | 230.74 |
| Solubility in Water | Soluble in Water |
| Melting Point | 235.0~240.0℃ |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one Hydrochloride (CAS: 151257-01-1), also known as Irbesartan Side Chain Hydrochloride, is an Intermediate of Irbesartan (Avapro) (CAS: 138402-11-6). Irbesartan is an angiotensin II receptor inhibitor, angiotensin II receptors are divided into AT1, AT2, irbesartan can inhibit AngⅠtransform into AngII by selectively blocking the AT1 receptor of AngII, specifically antagonize angiotensin converting enzyme 1 receptor (AT1), the antagonism of AT1 is 8500 times than that of AT2, it can inhibit vasoconstriction and aldosterone release by selectively blocking the binding AngII with AT1 receptor and result in the antihypertensive effect. This product does not inhibit angiotensin converting enzyme (ACE), renin, and other hormone receptors, neither suppress the blood pressure regulation and the balance of sodium ion channels. Irbesartan can also reduce electrical remodeling of the myocardium, thereby reduce the mortality rate of patients with hypertension, it is the most effective drug for treatment of hypertension and cardiovascular disease.
